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A one-compartmentvolume of distribution model is used to describe thecombined oxidative metabolites. SOD1 (21q22.1) is homodimer localized in thecytoplasm and in the mitochondrial intermembrane space, SOD2 (6q25.3) is tetramer inmitochondria and SOD3 (4p15.3 – p15.1) is tetramer localized extracellularly

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